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A breakthrough in 3D printed neuronal stem cells and scaffold therapy
3D printing is a manufacturing process that involves the creation of a 3D object from a digital design.
It has allowed more efficient and cost-effective production of intricate and sophisticated designs and has made great technological advances, including in healthcare.
The use of 3D printing has already revolutionised the prosthetics industry and has begun its transition into other therapy areas with the introduction of bio-printing – the ability to print live tissues and organs using an array of bio inks.
How to print a spinal cord
The University of Minnesota McAlpine research group specialises in the 3D printing of functional materials and devices and has a particular interest in developing biomedical devices and bionic organs.
One of its most recent projects has led to the creation of a 3D printed neuronal spinal cord scaffold.
It bioengineered the spinal cord using an array of bio inks and induced pluripotent stem cells, as well as spinal neuronal progenitor cells and oligodendrocyte progenitor cells.
These selected cells and materials were printed using novel 3D printing techniques specifically inside a 3D printed silicone scaffold, resulting in the formation of a multicellular complex encased in a silicone guide.
The cells were then cultured accordingly, and after one week the majority of cells had fully developed into neurons with axons extending down the scaffold.
Future hopes and challenges
It is hoped that eventually the 3D bio-printed spinal cord scaffold can be implanted into a human spinal cord and guide the growth of neurons to rebuild damaged neural connections.
However, there is still a long way to go before this sort of technology becomes an established therapy.
The next challenges the McAlpine research group faces are keeping all of the cells alive during the printing process, as well as integrating the technology in vivo so that it can be applied to a living organism.
According to WHO estimates, between 250,000 and 500,000 people suffer a spinal cord injury annually, most of these experiencing chronic pain or paralysis.
If 3D printed spinal cords are successfully developed and incorporated into a living organism, it will provide hope for those who have suffered long-term spinal injuries.
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